2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W051634
    Propargyl-PEG2-amine 944561-44-8 99.64%
    Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-amine
  • HY-141278
    Methyltetrazine-PEG4-maleimide 1802908-02-6 98.61%
    Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG4-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-PEG4-maleimide
  • HY-W451406C
    NH2-PEG2000-NH2 956496-54-1
    NH2-PEG2000-NH2 is a polyethylene glycol derivative containing two primary amine groups. The amino group can react quickly with activated carboxylic acid or carboxyl groups such as NHS esters to form stable amide bonds. The PEGylation of NH2-PEG-NH2 can increase solubility and stability, and reduce the immunogenicity of peptides and proteins, so it is mostly used to modify proteins, peptides and other substances.
    NH2-PEG2000-NH2
  • HY-W006445
    N-Boc-PEG2-bromide 165963-71-3 ≥98.0%
    N-Boc-PEG2-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG2-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG2-bromide
  • HY-W034595
    Eicosanedioic acid 2424-92-2 99.0%
    Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis
    Eicosanedioic acid
  • HY-141186
    TCO-OH 85081-69-2 99.91%
    TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    TCO-OH
  • HY-W092043
    TLR4-IN-C34-C2-COOH 1159408-54-4 99.94%
    TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34-C2-COOH can be used in the research of inflammation and acute myocardial injury. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
    TLR4-IN-C34-C2-COOH
  • HY-141119
    Boc-NH-PEG4-NHS ester 859230-20-9 99.07%
    Boc-NH-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG4-NHS ester
  • HY-140217
    Azido-PEG10-amine 912849-73-1
    Azido-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-amine
  • HY-140814
    Azido-PEG4-hydrazide 2170240-96-5 99.62%
    Azido-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-hydrazide
  • HY-140314
    DOTA-PEG5-C6-DBCO
    DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DOTA-PEG5-C6-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DOTA-PEG5-C6-DBCO
  • HY-140128
    DBCO-S-S-PEG3-biotin 1430408-09-5
    DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-S-S-PEG3-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-S-S-PEG3-biotin
  • HY-W088749
    tert-Butyl-hexanedioic acid 52221-07-5 98.69%
    tert-Butyl-hexanedioic acid is a PROTAC linker. tert-Butyl-hexanedioic acid can be used to synthesize PROTAC molecules, such as PROTAC ERα Degrader-12 (HY-174453).
    tert-Butyl-hexanedioic acid
  • HY-33846
    tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate 192130-34-0 99.88%
    tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate
  • HY-W091170
    Potassium (2-((tert-butoxycarbonyl)amino)ethyl)trifluoroborate 926280-83-3
    Potassium (2-((tert-butoxycarbonyl)amino)ethyl)trifluoroborate is a PROTAC linker that can be used in the synthesis of PROTACs.
    Potassium (2-((tert-butoxycarbonyl)amino)ethyl)trifluoroborate
  • HY-W043503
    tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate 873924-08-4
    tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate
  • HY-W102303
    (E)-tert-Butyldimethyl((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)allyl)oxy)silane 114653-19-9 ≥98.0%
    (E)-tert-Butyldimethyl((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)allyl)oxy)silane is a PROTAC linker that can be used in the synthesis of PROTACs.
    (E)-tert-Butyldimethyl((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)allyl)oxy)silane
  • HY-140150
    Azido-PEG3-Val-Cit-PAB-PNP 2055047-18-0 99.21%
    Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-Val-Cit-PAB-PNP
  • HY-W004701
    Br-C3-methyl ester 4897-84-1 99.12%
    Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    Br-C3-methyl ester
  • HY-42149
    NH2-PEG2-C2-Boc 756525-95-8 ≥98.0%
    NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    NH2-PEG2-C2-Boc
PROTAC Linkers Isoform Comparison

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